A number of Tottenham players have privately expressed concerns that Mauricio Pochettino's energy-sapping training sessions have contributed to the club's lengthy injury list.
However club sources claim the manager is unwilling to reduce the intensity of training.
Spurs' season has been disrupted by a host of fitness concerns which have played a part in their mixed start to the season.
Jan Vertonghen (hamstring), Moussa Dembele (thigh), Dele Alli (hamstring), Christian Eriksen (abdominal) and Serge Aurier (thigh) will all miss Saturday's home clash against Cardiff City through muscular injuries.
Hugo Lloris has only recently returned from a thigh muscle injury, while their has been persistent fitness concerns over talismanic striker Harry Kane.
Vertonghen, Dembele, Alli and Lloris all stayed until the final weekend in Russia following the respective successes of Belgium, England and France at the World Cup. Eriksen played in all four of Denmark's game's in Russia.
There is a sense that a number of Spurs' World Cup stars could benefit from a decreased workload given their arduous summers.
Tottenham players have often spoken glowingly about Pochettino's engaging training regime.
Pochettino believes the high octane nature of his sessions help ensure his team can play the pressing game he prefers.
Tottenham manager Pochettino is without five senior players because of muscle injuries for Saturday's clash with Cardiff and, although he refused to link Vertonghen's problem to fatigue, he issued a warning as the Premier League prepares to break for more international fixtures.
'It is dangerous,' said the Spurs boss. 'The football business today does not care about the player. It's all about games, games, games.'
With Mousa Dembele (thigh), Dele Alli (hamstring), Christian Eriksen (abdominal) and Serge Aurier (thigh) also out, Pochettino said: 'The problem comes because you need more players.
'The club has to spend a lot of money, you build a bigger squad with 25 players, and then you have another problem because not all can play.
'Then people are not happy and the fans, the media, the chairman and everyone says you need more players. But when they're all fit you have unhappy players because only 11 can play. It's so difficult.'
Tottenham face four big games in nine days when they return after the international break, starting against Manchester City and culminating in a crucial Champions League tie against PSV Eindhoven at Wembley. The introduction of UEFA's Nations League also means there are more competitive games and fewer friendlies.
'It is difficult to understand,' said Pochettino. 'You finish the World Cup then first international break you compete again in an official tournament.
'I understand the national team wants the best players. Our position is to understand the players, the national teams, FIFA and UEFA but who understands us?'
Alli's hamstring injury is a recurrence of a problem he first suffered on England duty. 'I can't blame England,' said Pochettino. 'They try to find the best for the player. The first responsibility is always the player's. He felt from the beginning a problem but carried on playing.
'Players always push to play. They want to play. For some it looks like a dishonour to be on the bench and they want to play even though they're tired.'
Pochettino was not impressed to find Belgium manager Roberto Martinez had told a press conference on Friday that Vertonghen's injury could rule him out of international games in mid-November. 'It's our player,' said the Spurs boss. 'Our Tottenham employee.'
He confirmed Vertonghen's injury was 'quite bad' but refused to put a time limit on his absence. He dismissed comparisons to Toby Alderweireld, out for three months last season with a hamstring injury, saying: 'Every player reacts differently to the same injuries.'
Vertonghen was hurt when he collided with Laurent Depoitre in last week's game at Huddersfield.
Like Alli, he carried on because he believed it was a dead leg and thought he could run through the pain. Spurs' medics realised at half-time that there was muscle damage and Vertonghen was replaced but it was too late.