Tottenham say they will play either Brighton or Crystal Palace in their first match in their new stadium in April.
An official statement said: "We are delighted to now be able to announce details for our two Test Event matches at our new stadium."
"In order to achieve a formal safety certificate for fixtures to be held at the new stadium, we are required to hold two Test Event matches with increasing levels of attendances."
"In respect of our opening game, this is subject to both a safety certificate and the outcome of Brighton & Hove Albion’s FA Cup match on Sunday 17 March."
"We have held discussions with the Premier League and UEFA. The following has been agreed with the Premier League, Brighton and Crystal Palace to ensure that our first game is a Premier League match prior to a UEFA Champions League quarter-final match"
If Brighton beat Millwall, the first match will be against Palace on Wednesday, April 3. If Brighton lose, they will be Spurs' first opponents in the new stadium on the weekend of April 6/7.
Champions League regulations state a club must play all of its home matches in the competition at the same venue, but UEFA can allow a switch in certain situations.
The first leg of the quarter-finals will be played on April 9 or 10, with the second leg a week later, meaning Spurs are guaranteed to play either Brighton or Palace before the first leg.