Video Assistant Referees (VAR) will be used at the UEFA Nations League finals in Portugal, which begin on June 5.
It marks the first time UEFA have used VAR in a UEFA National Team competition.
The move comes after the technology was successfully used in the UEFA Champions League knockout stages and the UEFA Europa League final.
A VAR team will be based at each stadium to support the referee and check for clear and obvious errors relating to goals, red cards, penalty-box incidents or mistaken identity.
The head coaches of the four participating nations were briefed in April by UEFA's chief refereeing officer Roberto Rosetti to prepare for the use of VAR at the finals.