Rangers are through to the Champions League play-offs despite defeat to Viktoria Plzen.
Russell Martin's side took a comfortable three-goal lead to the Czech Republic and it proved crucial as the hosts piled on the pressure.
Rafiu Durosinmi beat Jefte to fire in the opener just before half-time and the pressure continued after the break with Rangers also losing Cyriel Dessers to what looked like a serious knee injury.
Lyall Cameron turned in Danilo's ball to level the tie on the night, but after a string of impressive saves Jack Butland couldn't keep Svetozar Markovic's header out
The Ibrox side are now just one two-legged tie away from the prestige and prize money of the League Phase in Europe's elite tournament.