Arsenal travel to West Ham United, with Mikel Arteta's side looking to maintain their six-point lead at the top of the Premier League.
The Gunners come into the game off the back of a 2-2 draw against Liverpool - with Gabriel Martinelli and Gabriel Jesus netting for Arteta's side.
Despite being six points ahead of second place Manchester City, Arsenal have played one more game than Pep Guardiola's side and still have to travel to the Etihad Stadium.
As for West Ham, the Hammers come into the game off a 1-1 draw away to Gent in the Europa Conference League. David Moyes' side defeated Fulham 1-0 in their last league game and currently sit 14th in the table - three points off the relegation zone.
Mail Sport breaks down everything you need to know ahead of West Ham's meeting with Arsenal including how to watch and team news.
When is West Ham vs Arsenal?
West Ham's clash with Arsenal will take place on Sunday, April 16, with the game kicking off at 2.30pm.
The clash between the two sides will take place at the London Stadium, where the Hammers have won three of their last five games in all competitions.
Arsenal fans will be confident heading into the meeting with West Ham. The club have won four out of their last five meetings against the Hammers.
Gabriel Martinelli is the club's top scorer this season, with 14 goals in all competitions. The Brazilian winger has scored two goals in his last five games.
Jarrod Bowen is West Ham's top scorer in all competitions this season. The Englishman has scored nine goals for the club so far this campaign.
How to watch
Sunday's showdown between West Ham and Arsenal will be shown live on Sky Sports Main Event and Sky Sports Premier League, with coverage getting underway at 1pm.
The game between the two teams will also be streamed on the official Sky Go app.
Highlights will be uploaded to the official Sky Sports YouTube channel after the game.
Mail Sport will also be providing live coverage of West Ham vs Arsenal, so you can keep up-to-date with all the latest developments here.
Team news
The only main absentee for West Ham this weekend will be striker Gianluca Scamacca, who is set to have knee surgery.
Other than that, the Hammers should have a fully fit squad to choose from.
Said Benrhama, Michail Antonio, Tomas Soucek and Lucas Paqueta started on the bench West Ham's last game, but are all expected to start from the off against Arsenal.
As for the Gunners, the big news is that Eddie Nketiah will be back in the squad for the game.
The striker has been out of action for six weeks with an ankle problem, but has recently returned to training.
William Saliba is still out with a back issue that he sustained last month.
Following their last game against Liverpool, Arteta has no fresh injury concerns for the West Ham clash.
Predicted West Ham XI (4-3-3): Fabianski; Kehrer, Zouma, Ogbonna, Cresswell; Soucek, Rice, Paqueta; Benrahma, Antonio, Bowen
Predicted Arsenal XI (4-3-3): Ramsdale; White, Holding, Gabriel, Zinchenko; Odegaard, Partey, Xhaka; Saka, Jesus, Martinelli
What's been said?
Heading into the game, Arteta revealed that he is expecting a difficult game.
'[It will be a] very difficult game. We know, we’ve been there a few times and we always find really tricky and difficult games', Arteta said at his pre-match press conference.
'I know David really well and how he’s going to prepare for the game as well, and we are ready. It’s going to be a fight; it’s going to be another big derby for us and we’re going to be at our best to win it.'
The Spaniard also gave his thoughts on whether or not his side need a bit of luck in the title race.
'You need luck in the right moments. Why that luck comes is really important, how you think about it and what’s going to happen. It’s another part of this sport; sometimes it’s about inches and those inches need to go your way.'
As for the Hammer's Moyes is hoping that his side can give the league leaders a good game.
'We will put out a team that will try and beat Arsenal. Last year, we challenged a lot of the so-called 'big teams' so we will try to give them a good game', Moyes said at his pre-match press conference.
'They have got themselves in a great position [to possibly win the league.]'
Odds
West Ham to win - 5/1
Arsenal to win - 8/15
Draw - 3/1
West Ham to win, West Ham to have most shots on target and West Ham to have the most corners - 33/1
All odds via Paddy Power and correct at the time of publication.
Prediction
West Ham have endured a torrid season so far by this season and are currently fighting for safety.
They've shown that they can cause a few teams problems at the London Stadium and have the ability to do so against the league leaders.
As for Arsenal, they're top of the table for a reason and have been a joy to watch all season.
If the likes of Saka and Martinelli are firing from the off, it should be a comfortable day for Arteta's men.
Prediction - 2-0 Arsenal