Wolves are reluctant to risk Diogo Jota in Thursday's Europa League tie at Besiktas.
The Portuguese forward - a key man for coach Nuno Espirito Santo - is carrying a toe problem that caused him to miss the 2-0 win over Watford last weekend.
Jota has been managing the problem since before the 1-1 draw at Crystal Palace on September 22, even though he scored the injury-time equaliser in that game.
Diogo Jota is unlikely to be risked against Besiktas in the Europa League on Thursday evening
With only three days between the Besiktas game and the trip to champions Manchester City in the Premier League, Nuno is set to make changes in Istanbul.
Ruben Neves, left out of the starting XI for the last two league games, is pushing for a starting berth, as is £20million forward Patrick Cutrone, who has scored only once since his summer move from AC Milan.
European football has hit Wolves hard this season, with the win over Watford their first in seven games in the Premier League.
Morgan Gibbs-White is set to play a part in Istanbul, along with Ryan Bennett and Ruben Vinagre. Nuno's side are yet to get off the mark in the group after losing their opening fixture at home to Braga.
Wolves return to England straight after the match, meaning they will land in the early hours of Friday. Their only full training session, therefore, before the City game is likely to be on Saturday.
Nuno Espirito Santo is ready to make multiple changes in Istanbul due to fixture congestion.
