The 2025 Africa Cup of Nations concluded all the matches of the Round of 16, and the quarter-final pairings were thus determined.

Egypt, the team with the most titles in the history of the Africa Cup of Nations, will directly compete with defending champion Ivory Coast for a spot in the semi-finals, while host Morocco will face Cameroon.
Quarter-finals
Mali vs Senegal (1)
Egypt vs Ivory Coast (2)
Algeria vs Nigeria (3)
Cameroon vs Morocco (4)
Semi-finals
W1 vs W2
W3 vs W4
