Juventus were forced to rue wasteful finishing as they could only manage a draw away to Lecce on Saturday.
Match Reports
Sarri's decision to rest Ronaldo backfired as Juventus were forced to settle for a 1-1 draw at promoted Lecce.
De Ligt's handball enabled Mancosu to score from the spot in the 56th minute and earn the hosts their first home point of the Serie A season at Stadio Via del Mare.
Dybala, the hero of Juve's midweek Champions League win over Moscow, had not long earlier opened the scoring with a spot kick of his own.
But there was no late saviour for Sarri's men on this occasion, the loss of Pjanic to a muscle problem compounding a result that will force them back into second place if Inter beat Parma later on Saturday.
Serie A Standings
Match Events
14' Disallowed! Higuain scores but the goal is offside
Sandro is afforded time and space to fire a drive across the face of goal where the Argentine coasts in unmarked to convert in an empty net. However, the VAR has a check for offside and Higuain was early in his movement.
21' Higuain's shot wide out
Pjanic lifts the resulting free-kick into the box, but Higuain fails to connect with his header before the home side clear the danger.
26' Dybala's shot stopped by Gabriel
Danilo finds Dybala on the edge of the box and he drops his shoulder to surge into the box. The forward holds up to strike at goal on his left foot, only to plant his effort over the bar.
50' Penalty Goal! Lecce 0-1 Juventus (Dybala)
Dybala puts the visitors ahead as he curls his penalty low into the right bottom corner.
56' Penalty Goal! Lecce 1-1 Juventus (Mancosu)
The home side are back in the game as Mancosu strokes his effort past Szczesny into the net.
66' Injured Pjanic replaced by Khedira
Khedria replaces the injured Pjanic for the visitors.
