Mauricio Pochettino's men head to the Amex Stadium looking for their first win in three games in all competitions
Tottenham are fast approaching crisis point.
Never previously had they lost three consecutive games under Mauricio Pochettino, but they have been beaten by Watford, Liverpool and Inter in the space of the last month, and need a victory quickly.
A trip to Brighton may seem like an easy trip on paper, but the Seagulls have history of showing up the big boys - they have already beaten Manchester United this season - and fought back to claim a vital 2-2 draw with Southampton last week, having been 2-0 down.
TV Channel, Live Stream & How To Watch
In the United States (US), the game will be shown on NBCSN and streamed online via the NBC Sports Live app.
In the United Kingdom (UK), the game will be televised on BT Sport and streamed online through the BT Sport app.
Squads & Team News
Brighton will definitely be without Pascal Gross as he continues to recover from an ankle injury.
Jose Izquierdo faces a late fitness test, but there are unlikely to be many changes from the team that fought back against Southampton.
Potential Brighton XI: Ryan; Montoya, Duffy, Dunk, Bong; Stephens; Knockaert, Propper, Bissouma, March; Murray
Spurs played Inter without Toby Alderweireld and Kieran Trippier, but the pair could return against Brighton.
Hugo Lloris remains injured, but Michel Vorm has not impressed in his stead, perhaps leaving the door open for Paulo Gazzaniga.
Dele Alli and Moussa Sissoko are both back in training but are unlikely to be risked.
Potential Spurs XI: Gazzaniga; Trippier, Alderweireld, Vertonghen, Davies; Dembele, Dier; Lucas, Eriksen, Son; Kane
Betting & Match Odds
Spurs are 7/10 favourites to win on the road, according to bet 365, while a draw is available at 3/1. A win for the Seagulls is priced at 17/4.
Match Preview
Spurs look tired after their World Cup exertions - a number of players played in the maximum number of games, with Spurs players representing England, Belgium and France at the tournament - and need a pick-me-up.
Losses to Watford, Liverpool and Inter have led many to hit the panic button, with Harry Kane looking particularly jaded.
However, the main worry is the lack of tempo throughout those games, with their opponents simply seeming to want it more.
That attitude will not do on the south coast, with Brighton regularly relishing the underdog tag.
Their 3-2 win over Manchester United earlier this season was predicated on a solid foundation and a clinical striker up front - something Spurs fans should be familiar with.
There is no easy way to arrest Spurs' slump, but they must not assume victory will come easy here, as it is unlikely to.