Barca hadn't lost a single home league game between September 2016 and November 2018 until they faced Setien's Betis.
It was exactly Setien who ended Barca's unforgettable unbeaten home run which lasted for 792 days and 42 games.
The Catalans hadn't lost a single La Liga home match for more than two seasons. They lost 2-1 to Alaves on September 10, 2016. Since then, they hadn't lost until November 11, 2018.
And it was Quique Setien's Real Betis who inflicted the first-ever home defeat in more than two years. Barca lost 4-3 back then. Even Leo Messi's brace and Arturo Vidal's goal didn't help the Catalan giants.
By the way, after this game, Quique Setien received a special gift from his potential future player. Sergio Busquets handed him a signed shirt with a heartfelt message: "For Quique with appreciation and admiration for your way of understanding football. A hug."