Tottenham's reward for beating Manchester City is a quarter-final tie with Manchester United, while holders Liverpool go to Southampton.
Spurs upset Pep Guardiola's Premier League champions 2-1 at the Tottenham Hotspur Stadium on Wednesday night and will now take on Manchester United, who thrashed Leicester City 5-2.
Interim boss Ruud van Nistelrooy was in the dugout at Old Trafford for that win but Ruben Amorim could well be in charge by the time the quarter-final ties are played in the week commencing December 16.
Arsenal beat Preston 3-0 in their fourth-round tie to set up a last-eight date with Crystal Palace at the Emirates Stadium, while Newcastle knocked out last season's runners-up Chelsea at St James' Park and will be at home again when they play Brentford for a spot in the semis.
Quarter-final draw in full
Tottenham vs Man Utd
Arsenal vs Crystal Palace
Newcastle vs Brentford
Southampton vs Liverpool