Garnacho and Isak are among the players who could make first league appearances for their new clubs in Matchweek 4.
Arsenal - Piero Hincapie
Hincapie, who can play left-back and centre-back, started 28 Bundesliga matches for Bayer Leverkusen last season, suggesting he is a more than adequate back-up for the Gunners.
An injury to William Saliba means Hincapie might be thrown in at the deep end against Nottingham Forest on Saturday.
Chelsea - Alejandro Garnacho
Garnacho has enormous raw talent but Ruben Amorim could not fit him into his Man Utd side. However, there is plenty of time for Garnacho to be successful, having just turned 21 and with a fresh start at Chelsea.
The Argentinian winger will need to improve his output, however, to keep Pedro Neto out of the team. Garnacho contributed 24 goals or assists in 91 Premier League matches for United.
Liverpool - Alexander Isak
Having broken the British transfer record to sign him, Liverpool are ready to give Isak his debut – and all eyes are on how Arne Slot fits him into the side.
He trained with his new team-mates for the first time on Wednesday, two days after gaining his first match minutes of the season as a substitute for Sweden.
Isak scored 23 Premier League goals last season, coming second in the Golden Boot standings to his new team-mate Mohamed Salah.
Together, these two could get off to an explosive start at Burnley.
Manchester City - Gianluigi Donnarumma
Following the high-profile error made by James Trafford against Tottenham Hotspur, Man City decided to bring in a new goalkeeper, but the arrival of one of the few superstar No 1s around is not a guarantee of success.
Pep Guardiola wants someone reliable, but he also needs someone confident with the ball at his feet, and Donnarumma has been error-prone in this regard at Paris Saint-Germain.
That being said, he conceded just 20 goals from a post-shot xG of 30.4 in Ligue 1 last season, an enormous over-performance.
Man Utd - Senne Lammens
The pressure of being a Man Utd No 1 has taken down many a player over the years, which is why there is extra scrutiny on how a 23-year-old, with no experience outside Belgium, gets on in the Manchester derby this weekend.
Lammens is an excellent shot-stopper. In the Belgian Pro League last season, he conceded 30 goals from a post-shot xG of 44.5 (excluding own goals), putting him second overall across Europe’s top 10 leagues for goals prevented (14.5).
With his feet, there are some questions, mainly because he simply doesn’t face the kind of pressure in Belgium – literally and figuratively – as he will do in the Premier League.
Tottenham Hotspur - Randal Kolo Muani and Xavi Simons
Thomas Frank welcomes two of the most exciting forwards in Europe to Spurs, transforming their attack.
Muani scored nine goals in 13 matches on loan at Juventus in the second half of last season, showing why PSG paid £70 million for him two years ago.
It looks as though he is ready to be the goalscoring No 9 Spurs have been seeking since Harry Kane left.
Xavi Simons is another player who racks up superb numbers, hitting 0.67 goals or assists per 90 for RB Leipzig last season. He could play a starring role in James Maddison’s absence.