Wrexham go to Sheffield United in the first round of the Carabao Cup, while Leeds host Middlesbrough in an all-Championship clash and Wayne Rooney's Plymouth take on Cheltenham.
For the first time, you can watch every Carabao Cup game live on Sky Sports through the new Sky Sports+ streaming service, available to all Sky Sports customers at no extra cost.
The Carabao Cup first round will be played on the week commencing August 12.
Other standout ties include a south London match-up between EFL new arrivals Bromley and AFC Wimbledon, Portsmouth taking on Millwall and Chesterfield going to Derby.
When do Premier League teams enter the competition?
In the first and second round of this season's tournament the draw is regionalised, with the 32-team southern section and 38-team northern section drawn against another side from their part of the country.
Luton and Burnley, who finished 18th and 19th respectively in last season's Premier League, will enter the competition in the second round, as well as the 13 current Premier League clubs not involved in European competition. The remaining seven - defending champions Liverpool, Manchester City, Arsenal, Aston Villa, Tottenham, Chelsea and Manchester United will all enter the tournament from the third-round stage.
Round One Draw South in full
Cambridge vs QPR
Walsall vs Exeter
Crawley vs Swindon
Oxford United vs Peterborough United
Norwich City vs Stevenage
Bromley vs AFC Wimbledon
Portsmouth vs Millwall
Northampton Town vs Wycombe
Bristol City vs Coventry
Cardiff vs Bristol Rovers
Charlton vs Birmingham
Watford vs MK Dons
Swansea vs Gillingham
Plymouth vs Cheltenham
Leyton Orient vs Newport County
Colchester United vs Reading
Round One Draw North in full
Salford vs Doncaster
Rotherham vs Crewe
Carlisle United vs Stoke City
Leeds vs Middlesbrough
Barrow vs Port Vale
Burton Albion vs Blackpool
Tranmere Rovers vs Accrington
Fleetwood vs West Brom
Shrewsbury Town vs Notts County
Lincoln City vs Harrogate
Derby vs Chesterfield
Bolton vs Mansfield Town
Preston North End vs Sunderland
Sheffield United vs Wrexham
Huddersfield Town vs Morecambe
Wigan Athletic vs Barnsley
Hull City vs Sheffield Wednesday
Stockport vs Blackburn Rovers
Grimsby vs Bradford City