Another weekend with several huge league clashes is coming as we bring you all you need to know ahead of it.
Man City vs Chelsea
Kick Off: UTC 2019/11/23 17:30
Probable Lineups
Man City Team News
Rodri and David Silva made remarkable recoveries and are both expected to start here.
Guardiola will also hope to have Ederson available.
Bernardo Silva serves a one-match ban this weekend after admitting a breach of FA rules.
As neither Stones nor Otamendi have convinced of late, it wouldn't be a surprise if Fernandinho and Rodri started at centre-back.
Chelsea Team News
Jorginho will return to the starting XI after serving a one-match ban.
Azpilicueta will return at right-back on Saturday after dropping out of the team before the break.
Barkley failed to recover from injury in time to stay in England squad during the break and remains a doubt here.
Focus
Man City are winless in two matches in all competitions, they could be as many as 12 points behind Liverpool by the time they host Chelsea.
Chelsea have won their last six matches in the Premier League and have won five in a row away from home in the competition since losing 4-0 at Man Utd on the opening weekend.
City ran out 6-0 winners the last time they hosted Chelsea in the league.
Prediction
Man City 3-2 Chelsea
West Ham vs Tottenham
Kick Off: UTC 2019/11/23 12:30
Probable Lineups
West Ham Team News
Roberto will continue in goal despite his poor form.
Noble, Wilshere and Antonio will be included in the matchday squad after training all week without any problems.
Tottenham Team News
It's tough to see how Spurs will line up following the Wednesday morning appointment Mourinho.
Lloris and Vertonghen are ruled out for the game.
Lamela is a doubt with a thigh problem and will be assessed ahead of this one.
Focus
Spurs made the decision to sack Pochettino as Mourinho takes over for his first game in charge. He'll aim to improve Spurs' dire away form, which sees them mired on a 12-match winless run.
The Hammers were the first team to beat Spurs at the Tottenham Hotspur Stadium and they'd love nothing more than to inflict defeat upon their rivals following the appointment of Mourinho.
Prediction:
West Ham 1-1 Tottenham
Crystal Palace vs Liverpool
Kick Off: UTC 2019/11/23 10:00
Probable Lineups
Crystal Palace Team News
A foot injury forced Zaha off in Palace's 2-0 defeat to Chelsea Hodgson will be desperate to have his star man available here.
Former Liverpool centre-back Sakho will miss out once more but Kelly will start at right-back.
Another former Liverpool player, Benteke, may have to settle for a place on the bench.
Liverpool Team News
It has been reported neither Salah nor Robertson are expected to recover from ankle injuries in time to make it this weekend.
Shaqiri will hope to take Salah's spot in the team, but it's more likely Mane will swap over to the right wing and Origi will come in on the left.
Milner is the obvious replacement for Robertson, meanwhile.
Van Dijk withdrew from the Netherlands squad for personal reasons last weekend but should be available here.
Focus
With Man City hosting Chelsea in Saturday's late game, Liverpool know they could pull 12 points clear of the defending champions this weekend.
Crystal Palace are winless in their last four matches, though they have played Man City, Arsenal, Leicester and Chelsea in that time.
Prediction:
Crystal Palace 0-2 Liverpool
Sheffield Utd vs Man Utd
Kick Off: UTC 2019/11/24 16:30
Probable Lineups
Sheffield Utd Team News
Dean Henderson cannot start against his parent club.
Ravel Morrison came through the United academy but is unlikely, but former Red Norwood will start against his boyhood club.
Man Utd Team News
Dalot, Matic, Shaw and Tuanzebe all back in training. None are expected to start here, however.
Young is available again after serving a one-match ban before the international break.
McTominay has been nursing an ankle injury in recent weeks but is expected to start.
Pogba is nearing a first-team return but won't be ready until next month.
Focus
The Red Devils have won five of their last six matches in all competitions.
This is the first league meeting between the two sides since April 2007.
Before the weekend's action, only Leicester (8) had conceded fewer goals in the division than Sheffield United (9).
Prediction:
Sheffield Utd 2-2 Man Utd
Arsenal vs Southampton
Kick Off: UTC 2019/11/23 10:00
Probable Lineups
Arsenal Team News
Ceballos is still out for Arsenal with a hamstring injury.
Xhaka played for Switzerland during the break but is unlikely to feature for the Gunners.
Sokratis will hope for a recall after losing his place in the team against Leicester.
Southampton Team News
Cedric recovered from injury and Hasenhuttl will also recover Bertrand from suspension.
Focus
Arsenal head into the weekend's action eight points off the top four. The Gunners have only won two of their last 10 league matches.
Southampton have lost six of their last seven league matches and are now only one point off last place.
Prediction:
Arsenal 2-0 Southampton
Leganes vs Barcelona
Kick Off: UTC 2019/11/23 12:00
Probable Lineups
Leganes Team News
Jonathan Silva is back after a ban as Braithwaite and En-Nesyri should feature in attack.
Barcelona Team News
Semedo is injured, while Roberto is out due to suspension.
Wague will likely start at right-back with Firpo filling in for the injured Alba at left-back.
Griezmann, Suarez and Messi should be Valverde's front three.
Focus:
Barcelona bounced back to a couple of poor results with a 4-1 win over Celta Vigo.
Prediction:
Leganes 1-3 Barcelona
Real Madrid vs Real Sociedad
Kick Off: UTC 2019/11/23 20:00
Probable Lineups
Real Madrid Team News
Bale is unlikely to feature after his controversial behaviour with Wales.
Rodrygo is expected to get another start out on the right-hand side of Madrid attack.
Lucas Vázquez has broken a toe after dropping a weight on it. He is now sidelined for the home side.
Real Sociedad Team News
Odegaard will return for Real Sociedad against his parent club after a foot injury.
Focus
Real Madrid haven't conceded a goal in their last five consecutive games.
Zidane's side are yet to register a home defeat across all competitions so far this campaign.
Real Sociedad have lost just one of their last five league matches.
Prediction:
Real Madrid 3-2 Real Sociedad
Atalanta vs Juventus
Kick Off: UTC 2019/11/23 09:00
Probable Lineups
Atalanta Team News
Zapata is back in training but will likely only make the bench on Saturday.
Ilicic and Malinovskiy are suspended and will both miss out for Atalanta.
Juventus Team News
Ronaldo, Matuidi and Pjanic have recovered to full fitness and will start.
Sandro picked up an injury and will be replaced by De Sciglio.
Focus:
Juventus head into this game on the back of two consecutive clean sheets for the first time this season.
Atalanta have been a very tough opponent for Juventus in recent years.
Prediction:
Atalanta 2-2 Juventus
Milan vs Napoli
Kick Off: UTC 2019/11/23 12:00
Probable lineups
Milan Team News
Calhanoglu and Bennacer are out due to suspension and will be replaced by Rebic and Biglia.
Napoli Team News
Milik has an abdominal injury and is expected to miss out.
Focus
Napoli's season has taken an ugly turn in recent weeks, players have rebelled against president De Laurentiis.
Milan haven't been able to find consistency under Pioli, but there were positives in their defeat against Juventus.
Prediction:
Milan 1-1 Napoli
Flamengo vs River Plate
Kick Off: UTC 2019/11/23 20:00
Probable Lineups
Flamengo Team News
Gabigol's tally of 29 in 37 appearances makes him the deadliest forward in South America.
Everton Ribeiro starts on the right and De Arrascaeta pulls the strings in the middle.
Rafinha and Felipe Luis continue in the full-back positions with former Man City defender Pablo Mari in centre.
River Plate Team News
Quarta will partner Pinola in central defence with Montiel and Casco looking to push on from full-back.
Enzo Perez had given a worry when he injured his shoulder last week but is fit to anchor the midfield.
Focus
Gallardo's 2018 champions, River Plate, looking to defend their crown against Jorge Jesus' expensively assembled superstars, Flamengo in Copa Libertadores final.
Brazil against Argentina is always a little special and this will be the 15th final between two teams from the old rivals. Argentinian sides winning nine, but Brazil has captured the two most recent.
River will be playing their seventh Libertadores final and after losing their first two in 1966 and 1976, the Millonarios have won the last four. Flamengo meanwhile will be playing only they second Libertadores final after being crowned champions in 1981.
Prediction:
Flamengo 2-1 River Plate