Leicester's increasingly forlorn-looking pursuit of Premier League leaders Manchester City suffered a big blow as Arsenal came from behind to claim an impressive victory at the King Power Stadium.
Match Report
On a miserable afternoon at the end of a dire week for the Foxes, they also had influential winger Harvey Barnes carried off on a stretcher with his leg in a brace to add to their already considerable injury problems.
Things had started well for the hosts, who were given an early tonic for their midweek Europa League exit as Youri Tielemens was allowed to run unchecked down the right before firing a low shot into the far corner with just six minutes played.
Arsenal refused to be adversely affected, though, and took control of the game with impressive attacking intent and far greater fluency than Leicester.
David Luiz brought them level, finding space in the box to steer a header in from Willian's free-kick.
Alexandre Lacazette then put them ahead after the video assistant referee (VAR) judged that Wilfred Ndidi had blocked Nicolas Pepe's shot in the box with an outstretched arm.
It was second time lucky for the Gunners, who had earlier had a penalty awarded on the pitch but then downgraded to a free-kick after VAR decided the offending tackle on Pepe had taken place just outside the area.
Ivory Coast forward Pepe got in on the act himself, tapping into a largely unguarded net after Willian's pass had deflected his way.
Arsenal boss Mikel Arteta actually chose to rest a number of key players on Sunday, including Bukayo Saka and Pierre-Emerick Aubameyang, whose late winner had won their Europa League tie against Benfica on Thursday.
However, it came at a potential cost, though, with Emile Smith Rowe - such a bright spark in recent months - having to leave the field injured in the first half.
The Foxes' sixth home loss of the campaign leaves them 10 points behind a Manchester City side who have won their past 20 games.
Arsenal move up to ninth, eight points off the top four but with a renewed interest in events above them in the table.
Match Events
0' The match is about to start!
1' KICK-OFF! Who can win this match?
6' GOAL! Leicester 1-0 Arsenal (Tielemans)
15' Pepe goes down on the box side ref says penalty canceled after VAR check
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27' Willian's shot wide out
34' Aubameyang watches this game on the bench
38' GOAL! Leicester 1-1 Arsenal (Luiz)
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46' Penalty Goal! Leicester 1-2 Arsenal (Lacazette)
50' Injured! Barnes is stretchered off
51' GOAL! Leicester 1-3 Arsenal (Pepe)
72' Albrighton's shot blocked
78' Aubameyang is doing warm-up on the sidelines
84' Subs! Aubameyang replaces Lacazette
87' Aubameyang's shot inches wide
Line-ups
Leicester XI: Schmeichel, Evans, Vardy, Pereira, Tielemans, Castagne, Ndidi, Iheanacho, Soyuncu, Barnes, L. Thomas
Subs: Fuchs, Albrighton, Nampalys Mendy, Ward, Amartey, Under, Choudhury, V. Daley-Campbell, Sidnei Tavares
Arsenal XI: Willian, Luiz, Lacazette, Leno, Xhaka, Cedric, M.Elneny, Mari, Pepe, Tierney, Smith Rowe
Subs: Aubameyang, Ryan, Bellerin, Partey, M. Ødegaard, Ceballos, Holding, Martinelli, Saka