Following their comfortable 5-0 victory away at Sporting CP on Tuesday, Manchester City are set to host a struggling Tottenham Hotspur at the Etihad Stadium on Saturday in what is expected to be the most exciting game of the weekend in the Premier League.
Benjamin Mendy is still suspended by the club pending police investigation over rape and sexual assault charges while Zack Steffen, Jack Grealish, Cole Palmer and Gabriel Jesus are doubtful through injuries after missing out on the Champions League last-16 first leg in Portugal.
As for Spurs, Oliver Skipp and Japhet Tanganga are injury doubts, but Antonio Conte may be handed a huge boost, as starting centre-back Eric Dier could return after having been sidelined in the last three games through a knock.
Tottenham Hotspur have lost all their last three Premier League games against Chelsea, Southampton and the Wolverhampton Wanderers, with the last two defeats taking place on home soil.
Manchester City vs Tottenham Hotspur: Predicted line-ups
Manchester City's predicted line-up (4-3-3): Ederson; Kyle Walker, Ruben Dias, Aymeric Laporte, Joao Cancelo; Bernardo Silva, Rodri, Kevin De Bruyne; Riyad Mahrez, Phil Foden, Raheem Sterling.
Tottenham's predicted starting line-up (3-5-2): Hugo Lloris; Cristian Romero, Eric Dier, Ben Davies; Emerson Royal, Pierre-Emile Hojbjerg, Harry Winks, Rodrigo Bentancur, Sergio Reguilon; Harry Kane, Son Heung-min.
Manchester City vs Tottenham Hotspur: When does it start?
The Premier League clash between Manchester City and Spurs will get underway at 17:30 GMT, local time in England. That means a 12:30 (ET) and 09:30 (PT) kick-off for viewers in the USA.
Manchester City vs Tottenham Hotspur: Where to watch it?
UK residents can watch the game live on Sky Sports Main Event, Sky Sports Premier League and Sky Sports Ultra HD. For those living in the US, the duel will be broadcast on Peacock TV, fuboTV, NBC, NBC Sports App, UNIVERSO, Telemundo Deportes En Vivo, nbcsports.com, UNIVERSO NOW.