Wolves have sacked head coach Vitor Pereira after failing to win any of their 10 Premier League games this season.
A 3-0 defeat by Fulham on Saturday was Wolves' eighth of the top-flight campaign.
They are bottom of the table, eight points off safety.
Pereira took charge in December 2024 and signed a new three-year contract in September.
But a section of supporters turned on Pereira after the 3-2 loss to Burnley last week, when he was escorted away from heated discussions with fans after full-time at Molineux.
A club statement, which said all eight of Pereira's backroom staff have also left, said "results and performances this term have fallen below acceptable standards and as a result a change in leadership was deemed necessary".