Luis Suarez came off the bench to make his first appearance for boyhood team Nacional in over 16 years on Tuesday, but could not prevent them from slipping to 1-0 home loss to Brazil's Atletico Goianiense on Tuesday in the first leg of the Copa Sudamericana quarter-finals.
The 35-year-old recently rejoined Nacional after his contract with Atletico Madrid expired, and he was mobbed by the club's fans during his unveiling on Sunday.
He received another huge reception when he was thrown into the action to make his second debut for the side with just over 15 minutes to go in Montevideo as Nacional went in search of an equaliser after Luiz Fernando's first half opener for Goianiense.
Suarez almost grabbed an assist in the closing stages after his fine work on the left flank put team-mate Juan Ignacio Ramirez in a promising position, but Ramirez's effort hit the post.
Despite the disappointing result, Suarez still took the acclaim of the home fans after the final whistle.
He waved to supporters in the Uruguayan capital, and will hope to have a more positive impact on the pitch in the second leg of the last-eight tie.
The return leg will be played next Tuesday in Goiânia, in Brazil's heartland.
Winning the Copa Sudamericana, the second most prestigious club tournament in South American soccer, is a key objective for Suárez and his club.
Suarez's previous stint with Nacional was in 2005-06. He also played with a lot of success for Ajax, Liverpool and Barcelona during his time in European football, winning the Champions League back in 2015 with the latter club.
The veteran striker has scored 68 goals in 132 matches for Uruguay, and is hoping to remain fit enough to feature for his country in this year's World Cup which kicks off in November.
Uruguay have been drawn in Group H at the World Cup alongside Portugal, Ghana and South Korea.