Atletico Madrid host Manchester United in the first leg of their Champions League last-16 tie at the Estadio Wanda Metropolitano on Wednesday night.
This will be just the third time that the two teams have faced each other, with the last coming in the two-legged European Cup Winners' Cup in 1991/92, so this means that United goalkeeper David de Gea will be making his first return to face his boyhood club.
Another familiar face set to return to the Spanish capital is Cristiano Ronaldo, who made history during his time playing for Real Madrid, with Atleti having very bad memories of the Portuguese forward.
In terms of team news, Edinson Cavani is a doubt to play for United, yet there is some good news for Ralf Rangnick as Eric Bailly is set to be in the squad.
For Atleti, Matheus Cunha is out after suffering a knee injury against Levante. Antoine Griezmann was an unused substitute in Los Rojiblancos' 3-0 win at Osasuna last weekend, so he could get some minutes off the bench on Wednesday night. Koke is a doubt, though.
Atlético Madrid vs Man United predicted line-ups
Atletico Madrid's predicted line-up (4-4-2): Jan Oblak; Sime Vrsaljko, Stefan Savic, Josema Gimenez, Reinildo; Marcos Llorente, Koke, Geoffrey Kondogbia, Yannick Carrasco; Luis Suarez, Joao Felix.
Manchester United's predicted line-up (4-3-3): David de Gea; Diogo Dalot, Raphael Varane, Harry Maguire, Alex Telles; Bruno Fernandes, Scott McTominay, Paul Pogba; Marcus Rashford, Cristiano Ronaldo, Jadon Sancho.
When does Atlético Madrid vs Man United start?
Atletico vs Manchester United kicks off at the Estadio Wanda Metropolitano on Wednesday, February 23 at 21:00 CET, the local time in Madrid. That makes it a 20:00 kick off GMT for anyone in the United Kingdom, or for those in the United States the game will start at 15:00 ET/12:00 PT.
Where can I watch Atlético Madrid vs Man United?
Fans in the United Kingdom can tune in to watch Atletico vs Manchester United from 20:00 GMT on BT Sport 2 or on the BT Sport App. In the United States, meanwhile, European football fans will find Atletico vs Manchester United on Paramount+, TUDNxtra, and the TUDN App.