Gareth Bale is Real Madrid's high-profile member of the squad that has been linked with a move away this summer.
"[Gareth] will be with us [against Real Betis] tomorrow and that's all I can say," Zidane said. "I don't know if it'll be his last game, you can't tell. It's the end of the season and there will be changes."
Real Madrid have ended the season challenging for nothing having failed to defend their Champions League crown or challenge Barcelona in LaLiga Santander.
"It's clear that it's the last match and we've worked hard in order too finish the season well," Zidane said. "We want to give a good farewell to our fans, it's been a difficult year and we want to send a message to the fans that we'll come back with excitement and hard work so that they're proud of the players.
"We're going to give our all to change, I'm not going to say that we're going to win everything but we're going to prepare to have a great year, this I can assure you. It's been a difficult season and it's best that it ends."