There were two well-taken goals from Jakub Jankto and Gianluca Scamacca to decide the Derby della Lanterna.
Sampdoria were the favourites going in and took the lead when Jankto unleashed a ferocious strike from distance into the far top corner, surprising Mattia Perin.
Scamacca got Genoa back on track and netted his memorable first ever Serie A goal, turning on a Lukas Lerager assist.
Both Emil Audero and Perin made important saves, with Keita Balde Diao denied by the woodwork.
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