Manchester United have suffered another defensive injury this season after Victor Lindelof was ruled out of their crucial Champions League clash against Atalanta on Tuesday.
The club confirmed the Sweden international - who was part of the back three that started the 3-0 win at Tottenham on Saturday - has not travelled to Italy after picking up a knock in training on Monday.
It comes as a blow to Ole Gunnar Solskjaer, but has not resulted in the fully-fledged crisis United would have faced had he suffered the injury while Harry Maguire and Raphael Varane - his centre-back partners at the weekend - were still out.
But the injury to the 27-year-old Swede - who has played the full 90 minutes in all three of United's European fixtures so far this term - could force Solskjaer to change his system at the back once more, though Eric Bailly is a like-for-like replacement.
Meanwhile, Paul Pogba will be available to Solskjaer as his three-match ban following his dismissal in the 5-0 hammering by Liverpool only applies to domestic competitions.
Amad Diallo is also on the plane for the match against his former club while fellow forward Anthony Martial is also in the 25-man squad.
United lifted slightly lifted the pressure on under-fire boss Solskjaer at the weekend with their victory in north London, and will now look to take another step towards qualification for the last 16 of the Champions League in Bergamo.
But Solskjaer warned his Manchester United players that 'one swallow doesn't make a summer' as they try to build on the morale-boosting win over Tottenham.
'The next one is the one that matters and we've been looking and working to get consistency,' he said.
'We know that when we get that consistency, we well get results and performances.
'As I said, one swallow doesn't make a summer and it's important we keep focusing on what we did well in that game and improve on what we didn't do as well.
'It's relentless with games every three games, and it's a chance tomorrow to prove that we can go again.'
The Norwegian's side currently sit top of Group F, and have endured a topsy-turvy ride so far on the continent this term.
Their only away trip in Europe in 2021-22 ended in a shock defeat at Young Boys, before Cristiano Ronaldo-inspired comebacks saw them come from behind to beat both Villarreal and Atalanta.