Villarreal and Manchester United, the joint leaders of Champions League Group F, meet in Matchday Five of Europe's elite club competition on Tuesday evening with the chance to take a huge stride towards confirming a place in the knockout rounds. Both the LaLiga Santander and Premier League side find themselves on seven points, two above Atalanta and four clear of Young Boys at the bottom of a competitive group.
The pair last met on September 29 at Old Trafford in Matchday Two, where Paco Alcacer gave Villarreal the lead. But, Alex Telles levelled shortly after and a familiar foe in Cristiano Ronaldo scored a 95th minute winner to sink the Yellow Submarine.
The game in Spain will be Michael Carrick's first as Manchester United boss after Ole Gunnar Solskjaer lost his job following a 4-1 hammering against Watford over the weekend, yet they know a win will confirm their progression to the knockout rounds.
Villarreal, meanwhile, are coming into the game with a three-match unbeaten run behind them across LaLiga Santander and the Champions League.
Villarreal vs Manchester United: Predicted line-ups
Villarreal's predicted XI: Rulli; Foyth, Albiol, Torres, Pedraza; Parejo, Capoue, Coquelin; Pino, Dia, Danjuma.
Manchester United's predicted XI: De Gea; Wan-Bissaka, Bailly, Maguire, Dalot; Van de Beek, Fred; Sancho, Fernandes, Rashford; Cristiano Ronaldo Ronaldo.
Villarreal vs Manchester United: When does it start?
Villarreal vs Manchester United in the Champions League is one of Tuesday's early kick offs, with the start time set for 17:45 GMT - which is 18:45 CEST, the local time in Spain. Those in the United States will find kick off set for 12:45 ET or 09:45 PT.
Villarreal vs Manchester United: Where to watch it?
Viewers in the United Kingdom looking to watch Villarreal vs Manchester United can do so on BT Sport 3, or alternatively listen along on BBC Radio 5 Live. In the United States, football fans can tune in for Villarreal vs Manchester United on Paramount+ or TUDN USA.