It was almost a year ago on November 24, 2018, when Isco was substituted in Real Madrid's visit to Eibar under Santiago Solari's stewardship after a poor display, and it's hard to argue that he has ever recovered from that.
Zinedine Zidane didn't always utilise the Spaniard fully in his first spell in charge of Los Blancos, and little has changed in his second with Isco set to be on the bench once again in Saturday's clash with Eibar.
Isco had enjoyed incredible prominence in Julen Lopetegui's Spain and Real Madrid teams, but he has really dropped off the radar in terms of starting appearances since the Spanish coach's dismissal.
It's worth noting that Isco hasn't even been seen selected in Robert Moreno's La Roja squad for the upcoming international break.
Isco hasn't received a Spain call-up since the end of June, and he has to feel that his chances of playing at Euro 2020 are in serious jeopardy should the current situation continue.
Solari's relationship with Isco was virtually non-existent after the Spaniard's reaction to being withdrawn against Eibar and he was barely used again by the Argentine coach.
Prior to the disastrous defeat to Ajax in the Champions League, the former Malaga playmaker knew he wouldn't play, and as such he didn't attend the tactical meeting or travel to the ground on the team bus.
This infuriated Solari even further, although his own fate was sealed with a humbling elimination at the hands of the Amsterdam club.
"Most of the players have lived up to this badge and there are those who have not," Solari explained.
Injuries have plagued Isco's season to this point, he missed the entire month of September but has barely featured since.
He remains a great favourite of the club's supporters, but for now he can only hear this support from the bench.