Defending champions Napoli scored four times in the first half to beat Spezia 4-2 on Thursday night and reach the semi-finals of Coppa Italia.
Gennaro Gattuso's side will face Atalanta in the two-legged semi-finals. Atalanta beat Lazio 3-2 on Wednesday.
The other semi-final pits Juventus against Inter Milan.
Napoli took the lead with less than five minutes on the clock. Piotr Zielinski's effort was deflected onto the bar and the ball was then rolled across for Kalidou Koulibaly to score with a back-heeled flick from close range.
Zielinski then set up goals for Hirving Lozano and Matteo Politano before Eljif Elmas capped an impressive first-half performance when he slotted in Lorenzo Insigne's cross five minutes from the break.
Spezia briefly threatened a comeback as Emmanuel Gyasi and Gennaro Acampora scored within three minutes of each other midway through the second half.
Diego Demme hit the post for Napoli late on.