Roma's inconsistent performances continued after Jose Mourinho's team let a lead slip and lost 2-1 at home against Real Betis.
Luiz Henrique scored the winner in the 85th minute for the Spanish team and Roma had forward Nicolo Zaniolo sent off in injury time.
It was Roma's second loss of the campaign, with the team sitting in sixth place in Serie A.
Speaking to Sky Italy after the game, Mourinho said: 'Betis had more technical quality, especially in the first half, yet we had more chances and that is the contradiction of the game that hurts us, because we had the opportunities to score.
'It is easy to recognise they are a team with an elevated quality on the ball that caused us problems in the first half, but after that, the chances were all ours. Zaniolo hit the woodwork, Bravo made a save, we wasted two incredible chances, especially with Cristante.
'I thought a draw would've been the logical result and Betis were very happy to score a goal at the end.'
Paulo Dybala put the home side ahead from the penalty spot in 34th minute after VAR spotted a handball by Andres Guardado.
Betis equalised six minutes later when Guido Rodriguez unleashed a thunderbolt from 25-yards that found the bottom corner.
And a towering header from sub Luiz Henrique secured a dramatic victory.
Roma's frustration boiled over in added time when Nicolo Zaniolo was sent off.
The loss leaves Roma third in the group but Mourinho insisted that he still wanted to make it into the knockout stages, rather than drop down into the Europa Conference League, a competition they won last season.
